Vol. 15 nº 1 - Jan/Feb/Mar de 2021
Original Article Páginas: 69 a 78

Vascular mild cognitive impairment and its relationship to hemoglobin A1c levels and apolipoprotein E genotypes in the Dominican Republic

Authors Martin Medrano1; Gelanys Castro-Tejada1,2,; Rafael Lantigua3,4; Gretel Silvestre5,6; Sergio Diaz1,7,8; Patricia Mota6; Franck Diaz-Garelli9


keywords: vascular dementia, risk factors, apolipoproteins E, metabolic syndrome, diabetes mellitus.

Dementia and vascular mild cognitive impairment (VaMCI) currently impose a tremendous human and economic burden on patients from aging populations and their families worldwide. Understanding the interplay of cardiometabolic risk factors and apolipoprotein E (APOE) may direct us to a more personalized medicine and preventative care in MCI and dementia.
OBJECTIVE: To evaluate the relationship of cardiometabolic risk factors with MCI and assess the APOE genotype's role in an elderly cohort in the Dominican Republic.
METHODS: We studied a cohort of 180 participants 65 years of age and older using a combined assessment of cardiometabolic risk factors, neuropsychological battery tests, and APOE genotyping. We used the number of failed tests as a proxy to predict MCI.
RESULTS: We found that patients with the ε3-ε4 APOE genotype had 2.91 higher number of failed cognitive tests (p=0.027) compared to patients with the ε3-ε3 genotyped. The rate of test failures increased 10% (p=0.025) per unit increase in HbA1c percentage.
CONCLUSION: Increased Hemoglobin A1c levels and ε3-ε4 APOE genotypes seem to have an association with the development of VaMCI.


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