Vol. 14 nº 1 - Jan/Feb/Mar de 2020
Views & Reviews Páginas: 1 a 6

Depressive disorders in the elderly and dementia: an update

Authors Natália S. Dias1; Izabela G. Barbosa1,2; Weihong Kuang3; Antonio L. Teixeira1,4,5


keywords: depression, dementia, Alzheimer's disease, differential diagnosis, therapeutics.

The relationship between depressive disorders in the elderly and dementia, particularly Alzheimer's disease (AD), is highly complex. While the nature of this relationship is still a matter of debate, differential diagnosis and treatment remain a great clinical challenge. We review recent findings on the conundrum of depressive disorders in the elderly and AD. There is a biological continuum between depressive disorders in the elderly - or at least a subgroup of them - and AD. While elderly subjects with depression and patients with AD exhibit higher circulating levels of pro-inflammatory molecules and lower BDNF than matched controls, CSF levels of Aβ42 can discriminate AD from depressive disorders in the elderly. The role of antidepressant treatment as a strategy to minimize the risk of AD remains to be established.


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