Vol. 12 nº 4 - Oct/Nov/Dec de 2018
Original Article Páginas: 368 a 373

The Mini-Addenbrooke's Cognitive Examination (M-ACE) as a brief cognitive screening instrument in Mild Cognitive Impairment and mild Alzheimer's disease

Authors Diane da Costa Miranda; Sonia Maria Dozzi Brucki; Mônica Sanches Yassuda


keywords: dementia, cognition, Alzheimer's disease, cognitive dysfunction, neuropsychological tests, Brazil.

The Mini-Addenbrooke's Cognitive Examination (M-ACE) is a brief cognitive screening test that evaluates four main cognitive domains (orientation, memory, language and visuospatial function) with a maximum score of 30 points and administration time of five minutes.
OBJECTIVE: To assess the performance of healthy elderly, MCI patients and mild AD patients using the Brazilian version of the M-ACE.
METHODS: The test was applied to a group of 36 Mild Cognitive Impairment (MCI), 23 mild Alzheimer's Disease (AD) and 25 cognitive healthy elderly. All participants were aged ≥60 years.
RESULTS: The M-ACE displayed high internal consistency (Cronbach alpha >0.8; 95% CI 0.7-0.8) and proved effective for differentiating the AD group from MCI and control groups, providing superior accuracy than the MMSE (the cut-off point of 20 points had the highest sensitivity and specificity - 95.6% and 90.16% respectively, with a high area under the curve - AUC=0.8; 95% CI 0.7-0.9). Performance on the M-ACE was strongly correlated with that of the MMSE and Functional Activities Questionnaire (FAQ). The M-ACE was not accurate in discriminating MCI from control subjects.
CONCLUSION: The M-ACE is a brief screening test which provided high accuracy for diagnosing AD in this sample. The suggested cut-off point in this study was 20 points for AD.


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