Vol. 10 nº 4 - Oct/Nov/Dec de 2016
Views & Reviews Páginas: 267 a 275

Corticobasal syndrome: A diagnostic conundrum

Authors Jacy Bezerra Parmera1; Roberta Diehl Rodriguez1,2; Adalberto Studart Neto1; Ricardo Nitrini1; Sonia Maria Dozzi Brucki1

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keywords: corticobasal syndrome, corticobasal degeneration, dementia, atypical parkinsonism.

ABSTRACT:
Corticobasal syndrome (CBS) is an atypical parkinsonian syndrome of great interest to movement disorder specialists and behavioral neurologists. Although originally considered a primary motor disorder, it is now also recognized as a cognitive disorder, usually presenting cognitive deficits before the onset of motor symptoms. The term CBS denotes the clinical phenotype and is associated with a heterogeneous spectrum of pathologies. Given that disease-modifying agents are targeting the pathologic process, new diagnostic methods and biomarkers are being developed to predict the underlying pathology. The heterogeneity of this syndrome in terms of clinical, radiological, neuropsychological and pathological aspects poses the main challenge for evaluation.

 

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