Revisiting the neuropsychiatry of Huntington's disease
Antonio Lucio Teixeira1,2; Leonardo Cruz de Souza1; Natalia Pessoa Rocha1,2; Erin Furr-Stimming3; Edward C. Lauterbach4
keywords: Huntington's disease, neuropsychiatry, cognition, behavior.
Huntington's disease (HD) is an autosomal dominant neurodegenerative disease classified under the choreas. Besides motor symptoms, HD is marked by cognitive and behavioral symptoms, impacting patients' functional capacity. The progression of cognitive impairment and neuropsychiatric symptoms occur in parallel with neurodegeneration. The nature of these symptoms is very dynamic, and the major clinical challenges include executive dysfunction, apathy, depression and irritability. Herein, we provide a focused updated review on the cognitive and psychiatric features of HD.