Vol. 9 nº 1 - Jan/Feb/Mar de 2015
Views & Reviews Páginas: 2 a 8

Argyrophilic grain disease: an underestimated tauopathy

Authors Roberta Diehl Rodriguez1; Lea Tenenholz Grinberg2


keywords: argyrophilic grain disease, dementia, tauopathies, neurodegenerative diseases, pathology, postmortem

Argyrophilic grain disease (AGD) is an under-recognized, distinct, highly frequent sporadic tauopathy, with a prevalence reaching 31.3% in centenarians. The most common AGD manifestation is slowly progressive amnestic mild cognitive impairment, accompanied by a high prevalence of neuropsychiatric symptoms. AGD diagnosis can only be achieved postmortem based on the finding of its three main pathologic features: argyrophilic grains, oligodendrocytic coiled bodies and neuronal pretangles. AGD is frequently seen together with Alzheimer's disease-type pathology or in association with other neurodegenerative diseases. Recent studies suggest that AGD may be a defense mechanism against the spread of other neuropathological entities, particularly Alzheimer's disease. This review aims to provide an in-depth overview of the current understanding on AGD.


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