Vol. 7 nº 2 - Apr/May/Jun de 2013
Original Article Páginas: 216 a 220

Comparison of human brain metabolite levels using 1H MRS at 1.5T and 3.0T

Authors Fernando Fernandes Paiva1; Maria Concepcion Garcia Otaduy2; Ricardo de Oliveira-Souza3; Jorge Moll4; Ivanei Edson Bramati5; Luciane Oliveira6; Andrea Silveira de Souza7; Fernanda Tovar-Moll7

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keywords: brain, magnetic resonance spectroscopy, 1.5T, 3.0T.

ABSTRACT:
Proton magnetic resonance spectroscopy (MRS) of the human brain has proven to be a useful technique in several neurological and psychiatric disorders and benefits from higher field scanners as signal intensity and spectral resolution are proportional to the magnetic field strength.
OBJECTIVE: To investigate the effects of the magnetic field on the measurement of brain metabolites in a typical routine clinical setting.
METHODS: Single voxel spectra were acquired from the posterior cingulate cortex in 26 healthy subjects. Each subject was scanned consecutively at 1.5T and 3.0T in a randomly distributed order.
RESULTS: SNR and peak width improvements were observed at higher fields. However, SNR improvement was lower than the theoretical two-fold improvement. Other than the values obtained for creatine (Cre) and myo-Inositol (mI), which were both higher at 3.0T, all metabolite concentrations obtained were roughly the same at both field strengths. All the metabolite concentrations were estimated with a Cramer Rao lower bounds (CRLB) lower than 15% of the calculated concentrations.
CONCLUSIONS: Even though the present study supports the expected benefits of higher field strength for MRS, there are several factors that can lead to different quantitative results when comparing 1.5T to 3.0T MRS. Future comparative studies are necessary to refine the metabolite thresholds for early detection and quantification of distinct neurological and psychiatric disorders using 3.0T MRS.

 

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