Vol. 7 nº 2 - Apr/May/Jun de 2013
Original Article Páginas: 197 a 205

Cognitive anosognosia and behavioral changes in probable Alzheimer's disease patients

Authors Corina Satler1; Carlos Tomaz2


keywords: awareness, anosognosia, insight, aging, Alzheimer's disease, dementia.

Anosognosia, impairment insight and unawareness of deficits are used as equivalent terms in this study.
OBJECTIVE: To investigate the relationship between the presence of anosognosia symptoms and cognitive domains, functional abilities, and neuropsychiatric symptoms in patients with probable Alzheimer's disease (pAD) and elderly controls (EC).
METHODS: Twenty-one pAD (14 women) and twenty-two EC (16 women) were submitted to a neuropsychological battery of tests assessing global cognitive status, and specific cognitive functions: memory, executive and attention functions, verbal fluency and visuoconstructive abilities. Additionally, functional abilities (FAQ) and neuropsychiatric symptoms (NPI) were measured.
RESULTS: The linear regression statistical test found general anosognosia to be associated with subjective memory complaints, age and Arithmetic-DRS in the EC group. On the other hand, cognitive and functional abilities scores (Arithmetic-DRS, IQCODE and FAQ) were the best predictors in pAD patients, particularly for behavioral awareness.
CONCLUSION: These results indicated that different variables are associated with self-awareness for pAD patients and EC, but for both groups executive functions appear to play an important role, contributing particularly to awareness of behavioral changes.


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