Vol. 6 nº 4 - Oct/Nov/Dec de 2012
Case Report Páginas: 290 a 295

Adult-onset adrenoleukodystrophy presenting as a psychiatric disorder: MRI findings

Authors Antonio Cézar Ribeiro Galvão1; Gislaine Cristina Lopes Machado-Porto2; Fábio Henrique de Gobbi Porto3; Leandro Tavares Lucato2; Ricardo Nitrini4

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keywords: leukoencephalopathies, leukodystrophies, adult-onset adrenoleukodystrophy, magnetic resonance imaging.

ABSTRACT:
A 35-year-old, previously healthy man presented psychiatric symptoms lasting four years, receiving treatment with neuroleptics. One year later he evolved with gait disequilibrium. After a further six months, cognitive symptoms were characterized with rapid evolution to a profound demented state. MRI showed signal changes in cerebral white matter and very long-chain fatty acids were detected in blood.

 

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