Vol. 5 nº 4 - Oct/Nov/Dec de 2011
Views & Reviews Páginas: 303 a 309

Cognitive impairment in multiple system atrophy: Changing concepts

Authors Agessandro Abrahão; Livia Almeida Dutra; Pedro Braga Neto; José Luiz Pedroso; Ricardo Araújo de Oliveira; Orlando Graziani Povoas Barsottini


keywords: multiple system atrophy, cognitive impairment, dementia, atypical parkinsonism, neuropsychological evaluation.

Multiple system atrophy (MSA) is characterized by a variable combination of cerebellar ataxia, parkinsonism and pyramidal signs associated with autonomic failure. Classically, cognitive impairment was not considered a clinical feature of MSA and dementia was pointed out as an exclusion diagnostic criteria. Based on comprehensive neuropsychological assessment, cognitive impairment was found to be a frequent feature in MSA, and clinically-defined dementia is now reported in 14-16% of cases. This article reviews the current data on cognitive impairment in MSA along with its neuropsychological profile and pathophysiology.


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