Vol. 3 nº 4 - Oct/Nov/Dec de 2009
Case Report Páginas: 352 a 357

Non-inflammatory cerebral amyloid angiopathy as a cause of rapidly progressive dementia: A case study

Authors Leonel Tadao Takada1,2, Paulo Camiz3, Lea T. Grinberg4,5, Claudia da Costa Leite6


keywords: dementia, cerebral amyloid angiopathy, vascular dementia.

A 77 year-old men developed a subacute-onset, rapidly progressive cognitive decline. After 6 months of evolution, he scored 6 on the Mini-Mental State Examination and had left hemiparesis and hemineglect. The patient died 11 months after the onset of cognitive symptoms. Brain MRI showed microhemorrhages on gradient-echo sequence and confluent areas of white matter hyperintensities on T2-weighted images. Brain biopsy revealed amyloid-β peptide deposition in vessel walls, some of them surrounded by micro-bleeds. In this case report, we discuss the role of cerebral amyloid angiopathy (CAA) in cognitive decline, due to structural lesions associated with hemorrhages and infarcts, white matter lesions and co-morbidity of Alzheimer's disease, as well as the most recently described amyloid angiopathy-related inflammation.


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