Vol. 3 nº 4 - Oct/Nov/Dec de 2009
Views & Reviews Páginas: 268 a 274

Diffusion tensor imaging for Alzheimer's disease A review of concepts and potential clinical applicability

Authors Luciano de Gois Vasconcelos1, Sonia Maria Dozzi Brucki2, Andrea Parolin Jackowiski3, Orlando Francisco Amodeo Bueno4


keywords: Alzheimer's disease, magnetic resonance imaging, early diagnosis, review.

In view of the urgent need to identify an early and specific biomarker for Alzheimer's disease (AD), a PubMed database search was performed using the terms "Alzheimer disease" and "Diffusion Magnetic Resonance Imaging" to enable review of Diffusion tensor imaging (DTI) concepts and its potential clinical role in AD evaluation. Detailed analysis of selected abstracts showed that the main DTI measures, fractional anisotropy and apparent diffusion coefficient, indicators of fiber tract integrity, provide a direct assessment of WM fibers and may be used as a new biomarker for AD. These findings were found to correlate with cognitive assessments, rates of AD progression and were also able to differentiate among groups including mild cognitive impairment, AD, and other dementias. Despite several consistent DTI findings in AD patients, there is still a lack of knowledge and studies on the DTI field. DTI is not yet ready for clinical use, and requires extensive further research in order to achieve this goal.


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