Vol. 3 nº 1 - Jan/Feb/Mar de 2009
Case Report Páginas: 68 a 72

Dementia post-radiotherapy: improvement with acetylcholinesterase inhibitor. A case report

Authors Antonio Eduardo Damin1,2, Lílian S. Morillo1,3, Tíbor Rilho Perroco1,4, Wilson Jacob Filho1,3, Cássio Machado de Campos Bottino1,4


keywords: dementia, therapeutics, radiotherapy, cholinesterase inhibitors.

Cognitive decline associated with radiotherapy is a progressive complication that affects many patients submitted to this form of treatment. The lack of an effective treatment drives research for new treatment options to improve the quality of life of patients with this disorder. We report the case of a 64 year-old man who developed a severe dementia of the frontal subcortical type, which was associated with subcortical frontal lesions and appeared as a late complication of radiotherapy used to treat a pituitary tumor. After many pharmacological attempts to improve his cognitive and behavioral problems, the patient showed a significant improvement in the cognitive, functional and behavioral impairments after treatment with an acetylcholinesterase inhibitor. This report discusses hypotheses for the positive effect of this treatment.


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