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Figure 1
Description: Figure 1. Proposed theory for brain dysfunction in Chagas disease. Chagas disease causes both structural heart damage and chronic activation of the immune system, mostly by Th1-type cytokines. Structural cardiomyopathy and chronic inflammation exert independent and synergistic effects on ischemic stroke risk, while chronic inflammation may induce brain atrophy. Finally, both multiple brain infarcts and brain atrophy impact brain dysfunction such as motor and cognitive deficits.
Article Details
Vol. 3 nº 1 - Jan/Feb/Mar - 2009
Stroke and brain atrophy in chronic Chagas disease patients: a new theory proposition
Authors: Jamary Oliveira-Filho


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